DBS (Deep brain stimulation) has become a safe and effective for treatment of the neurological movement disorders such as those happen in Parkinson’s disease (PD). During DBS, implanted electrodes are used into specific targets such as the subthalamic nucleus (STN). Diffuse Reflectance Spectroscopy (DRS) has been used to study biological tissue in many applications and can be used as a non-invasive technique to analyze a given material’s reflectance spectrum characteristics produced as light passed through a medium.
This technique takes advantage of the brain’s white and grey matter different reflectivity near STN. It is usually performed by using a broadband white light source, some sort of optic probe for delivering the light to and from the instruments, and spectral analysis is done by a spectrometer. Spectroscopy in the brain tissue can also provide information due to blood content based on the strong absorbers in blood (deoxygenated and oxygenated hemoglobin).